[HTML][HTML] From bedside to bench-in vivo and in vitro evaluation of mechanically assisted cough treatment in a patient with bulbar amyotrophic lateral sclerosis

T Andersen, O Fondenes, OD Røksund… - Respiratory Medicine …, 2022 - Elsevier
… with Amyotrophic Lateral Sclerosis, the … Amyotrophic Lateral Sclerosis experienced that
treatment with MI-E was exhausting and inefficient. Despite adjustments of settings, all treatment

[HTML][HTML] A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

X Xu, D Shen, Y Gao, Q Zhou, Y Ni, H Meng… - Translational …, 2021 - Springer
treatment of spasticity in ALS patients, as they can control spasticity with safety and efficacy
in multiple sclerosis [58… cohort study has revealed high treatment satisfaction with nabiximols, …

[HTML][HTML] Inosine in neurodegenerative diseases: From the bench to the bedside

MS Basile, P Bramanti, E Mazzon - Molecules, 2022 - mdpi.com
… its safety and efficacy and its use as a complementary therapy along with other approved
drugs. … Urate levels predict survival in amyotrophic lateral sclerosis: Analysis of the expanded …

Therapeutic approaches to amyotrophic lateral sclerosis from the lab to the clinic

VP Chavda, C Patel, D Modh, YN Ertas… - Current Drug …, 2022 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects adults and
… from bench to bedside in the field of ALS treatment. More than 160 drug candidates or ther…

[HTML][HTML] Translational study for amyotrophic lateral sclerosis treatment

S Schröder, G Litscher, W Pan - Frontiers in Neurology, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive
loss of upper and lower motor neurons. Despite significant scientific efforts in the last …

[HTML][HTML] Neuroimaging findings in preclinical amyotrophic lateral sclerosis models—How well do they mimic the clinical phenotype? A systematic review

AE Cannon, WE Zürrer, C Zejlon, Z Kulcsar… - Frontiers in Veterinary …, 2023 - frontiersin.org
… This opposes the high attrition of drugs during bench-to-bedside translation … drug development.
These findings emphasize a careful application of these model systems for ALS therapy

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)

E Abati, N Bresolin, G Comi, S Corti - Expert opinion on therapeutic …, 2020 - Taylor & Francis
… the small study sample and the low treatment doses received by patients. Another silencing
… RNAi therapy from the bench to the bedside is the lack of an in vivo biomarker of therapeutic

[HTML][HTML] Stathmin 2 is a potential treatment target for TDP-43 proteinopathy in amyotrophic lateral sclerosis

Y Liu, D Yan, L Yang, X Chen, C Hu… - Translational …, 2024 - Springer
… could be a barrier to axonal outgrowth/regeneration during patient treatment. Despite the
gap from bench to bedside, STMN2 is a potential therapeutic target for TDP-43 proteinopathy. …

[HTML][HTML] Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
… ), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease
(… and treatments that can reshape the gut microbiome, serving as potential therapies for NDs (…

[HTML][HTML] Organ on a chip: a novel in vitro biomimetic strategy in amyotrophic lateral sclerosis (ALS) modeling

B Arjmand, S Kokabi Hamidpour, Z Rabbani… - Frontiers in …, 2022 - frontiersin.org
treatment has been found for amyotrophic lateral sclerosis (… the disease, multiple medical
therapies have been proposed … translational researches from bench to bedside in various …